G6PDi-1 B( —— )

Catalog No. M37586 CAS No. 2457232-14-1

G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	49	Get Quote
5MG	76	Get Quote
10MG	132	Get Quote
25MG	266	Get Quote
50MG	426	Get Quote
100MG	614	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

G6PDi-1 B
Note

Research use only, not for human use.
Brief Description

G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
Description

G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50?of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

Dehydrogenase
Research Area

——
Indication

——

Chemical Information

CAS Number

2457232-14-1
Formula Weight

284.34
Molecular Formula

C14H12N4OS
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (175.85 mM; Ultrasonic )
SMILES

O=C1CCCCc2nc(Nc3csc(c3)C#N)ncc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Jonathan M Ghergurovich, et al. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020 Jul;16(7):731-739.?

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